Previous studies have shown that patients with COPD have an increased risk of frailty compared with non-COPD individuals, and it is associated with increased fat mass which is directly linked with physical inactivity and comorbidities 1, 2, 6, 7. Frailty reflects a lack of resilience of physiological systems to abnormal stressors which can be characterised by a number of deficits including loss of musculoskeletal mass and strength, increased number of comorbidities, cognition deficit, and progressive deterioration in physical capacity 1, 2, 5. Patients with chronic obstructive pulmonary disease (COPD) are more prone to be frail compared to non-COPD individuals and it is not necessarily driven by age 1, 2, 3, 4. The TUG is a simple, easy and quick measure that could be easily applied in restricted settings to screen for frailty in COPD. The TUG showed the ability to discriminate between frail and non-frail patients with COPD, independent of age and severity of the airflow obstruction. The TUG discriminated between frail and non-frail patients with COPD with an area under the curve of 72 (95% CI: 67–76), and a diagnostic odds ratio of 2.67 (95% CI:1.5–4.6), P < 0.001. Frail patients with COPD had a greater TUG time (11.55 ± 4.03 s) compared to non-frail patients (9.2 ± 1.6 sec), after controlling for age and lung function ( F = 15.94, P < 0.001), and both were greater than the controls (8.3 ± 1.2 sec), P < 0.001. The patients with COPD and controls were similar in age, sex and BMI but the patients with COPD were more frail, mean ± SD FI 0.16 ± 0.08 than controls 0.05 ± 0.03, P < 0.001. A ROC curve was used to identify how well TUG discriminates between frail and non-frail patients with COPD. All participants were assessed for lung function and body composition. The TUG was used to assess physical mobility. Frailty was assessed in 520 patients diagnosed with COPD and 150 controls using a Comprehensive Geriatric Assessment questionnaire and frailty index (FI) was derived. We hypothesised that the TUG would identify frail patients with COPD. Frail patients with chronic obstructive pulmonary disease (COPD) are usually undiagnosed. The Timed Up and Go (TUG) is a global measure of mobility and has the ability to detect frail individuals.
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